Regional Entrepreneurial Opportunities in the Biotech Industry: Exploring the Transition from Award-winning Nascent Entrepreneurs to Real Start-ups
H. Wolf, Claus Michelsen, Michael Schwartz
Abstract
Knowledge of factors that determine the transition from nascent entrepreneurship into real entrepreneurship is of major importance for policies aiming to effectively stimulate start-ups. Whereas scholars concentrated on person-specific factors to explain transition probabilities, environmental characteristics have been fairly neglected. Given that entrepreneurship is a strongly localized phenomenon, this paper argues that regional entrepreneurial opportunities are a driving force behind the transition from nascent entrepreneurship to new venture creation. Based on unique data on 103 nascent entrepreneurs in the German biotechnology industry, we empirically assess the importance of regional entrepreneurial opportunities on transition probabilities. Further, we introduce a new
approach to measure nascent entrepreneurship by capturing individuals that actively participate in start-up competitions and have won at least one competition. Controlling for technology and individual characteristics, we find strong support for our hypotheses relating to the significant impact of general regional opportunities, specific regional opportunities and the entrepreneurial environment for the probability of transition from award-winning nascent entrepreneurs to real start-ups.
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How Does Industry Specialization Affect the Efficiency of Regional Innovation Systems?
Michael Fritsch, Viktor Slavtchev
Annals of Regional Science,
Nr. 1,
2010
Abstract
This study analyzes the relationship between the specialization of a region in certain industries and the efficiency of the region in generating new knowledge. The efficiency measure is constructed by relating regional R&D input and output. An inversely u-shaped relationship is found between regional specialization and R&D efficiency, indicating the presence of externalities of both Marshall and Jacobs’ type. Further factors influencing efficiency are externalities resulting from high R&D intensity of the local private sector as well as knowledge from local public research institutions. The impact of both the specialization and the additional factors is, however, different for regions at different efficiency levels.
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Metformin-Therapie bei PCO-Syndrom - Positive Vierjahresbilanz des oralen Antidiabetikums
D. Albrecht, P. Kaltwasser, E. Rosenkranz, Dirk Trocka
MedReview,
2007
Abstract
Das Polyzystische Ovarialsyndrom (PCOS) ist mit einer Krankheitshäufigkeit von 4–12 % die häufigste endokrine Erkrankung der Frau im reproduktiven Alter. Neben dem unerfüllten Kinderwunsch stellt es ein hohes Risiko für metabolische (stoffwechselbedingte) und kardiovaskuläre (Herz und Blutgefäße betreffende) Erkrankungen dar. Die Studie stellt die ersten Ergebnisse der Behandlung des PCOS mit dem oralen Antidiabetikum Metformin in einer Vierjahres-Analyse dar und versucht Kriterien für den Einsatz des Arzneistoffes zu definieren.
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Industry Specialization, Diversity and the Efficiency of Regional Innovation Systems
Michael Fritsch, Viktor Slavtchev
Determinants of Innovative Behaviour,
2008
Abstract
Innovation processes are characterized by a pronounced division of labor between actors. Two types of externality may arise from such interactions. On the one hand, a close location of actors affiliated to the same industry may stimulate innovation (MAR externalities). On the other hand, new ideas may be born by the exchange of heterogeneous and complementary knowledge between actors, which belong to different industries (Jacobs’ externalities). We test the impact of both MAR as well as Jacobs’ externalities on innovative performance at the regional level. The results suggest an inverted u-shaped relationship between regional specialization in certain industries and innovative performance. Further key determinants of the regional innovative performance are private sector R&D and university-industry collaboration.
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How Does Industry Specialization Affect the Efficiency of Regional Innovation Systems?
Michael Fritsch, Viktor Slavtchev
Jena Economic Research Papers, Nr. 2008-058,
Nr. 58,
2008
Abstract
This study analyzes the relationship between the specialization of a region in certain industries and the efficiency of the region in generating new knowledge. The efficiency measure is constructed by relating regional R&D input and output. An inversely u-shaped relationship is found between regional specialization and R&D efficiency, indicating the presence of externalities of both Marshall and Jacobs’ type. Further factors influencing efficiency are spillovers within the private sector as well as from public research institutions. The impact of both the specialization and the additional factors is, however, different for regions at different efficiency levels.
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Industry Specialization, Diversity and the Efficiency of Regional Innovation Systems
Michael Fritsch, Viktor Slavtchev
Jena Economic Research Papers, Nr. 2007-018,
Nr. 18,
2007
Abstract
Innovation processes are characterized by a pronounced division of labor between actors. Two types of externality may arise from such interactions. On the one hand, a close location of actors affiliated to the same industry may stimulate innovation (MAR externalities). On the other hand, new ideas may be born by the exchange of heterogeneous and complementary knowledge between actors, which belong to different industries (Jacobs’ externalities). We test the impact of both MAR as well as Jacobs’ externalities on innovative performance at the regional level. The results suggest an inverted u-shaped relationship between regional specialization in certain industries and innovative performance. Further key determinants of the regional innovative performance are private sector R&D and university-industry collaboration.
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What Determines the Efficiency of Regional Innovation Systems?
Michael Fritsch, Viktor Slavtchev
Jena Economic Research Papers, Nr. 2007-006,
Nr. 6,
2007
Abstract
We assess the efficiency of regional innovation systems (RIS) in Germany by means of a knowledge production function. This function relates private sector research and development (R&D) activity in a region to the number of inventions that have been registered by residents of that region. Different measures and estimation approaches lead to rather similar assessments. We find that both spillovers within the private sector as well as from universities and other public research institutions have a positive effect on the efficiency of private sector R&D in the respective region. It is not the mere presence and size of public research institutions, but rather the intensity of interactions between private and public sector R&D that leads to high RIS efficiency. We find that relationship between the diversity of a regions’ industry structure and the efficiency of its innovation system is inversely u-shaped. Regions dominated by large establishments tend to be less efficient than regions with a lower average establishment size.
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Equity and Bond Market Signals as Leading Indicators of Bank Fragility
Reint E. Gropp, Jukka M. Vesala, Giuseppe Vulpes
Journal of Money, Credit and Banking,
Nr. 2,
2006
Abstract
We analyse the ability of the distance to default and subordinated bond spreads to signal bank fragility in a sample of EU banks. We find leading properties for both indicators. The distance to default exhibits lead times of 6-18 months. Spreads have signal value close to problems only. We also find that implicit safety nets weaken the predictive power of spreads. Further, the results suggest complementarity between both indicators. We also examine the interaction of the indicators with other information and find that their additional information content may be small but not insignificant. The results suggest that market indicators reduce type II errors relative to predictions based on accounting information only.
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Measuring the Efficiency of Regional Innovation Systems – An Empirical Assessment
Michael Fritsch, Viktor Slavtchev
Freiberg Working Papers, Nr. 08-2006,
Nr. 8,
2006
Abstract
Wir messen die Effizienz der regionalen Innovationssysteme (RIS) in Deutschland anhand einer Wissensproduktionsfunktion. Diese Funktion stellt einen Zusammenhang zwischen der Anzahl der von den Einwohnern einer Region angemeldeten Patente und der Anzahl der FuE-Beschäftigten im Privatsektor in der Region. Zwei alternative Methoden zur empirischen Berechnung der Wissensproduktionsfunktion werden vorgestellt. In einem ersten Ansatz nehmen wir an, dass sich Unterschiede der Produktivität der FuE-Beschäftigten in der Steigung der Wissensproduktionsfunktion und somit in der Grenzproduktivität der FuE-Aktivitäten niederschlagen. Ein zweiter Ansatz bestimmte die Durchschnittsproduktivität der FuE-Beschäftigten mittels einer stochastischen Frontier-Wissensproduktionsfunktion. Wir vergleichen die Resultate beider Ansätze und diskutieren kritische Fragen hinsichtlich der Verteilungscharakteristika der technischen Effizienz von Regionen, der adäquaten Größe regionaler Innovationssysteme sowie der Präsenz und der Effekte räumlicher Interdependenzen zwischen den Regionen (räumlicher Autokorrelation).
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The Role of Regional Knowledge Sources for Innovation – An Empirical Assessment
Michael Fritsch, Viktor Slavtchev
Freiberg Working Papers, Nr. 15-2005,
Nr. 15,
2005
Abstract
Wir untersuchen die Bedeutung verschiedener Inputs, insbesondere verschiedener Wissensquellen, für den regionalen Output an Erfindungen (Patente) mithilfe einer Wissensproduktionsfunktion. Als Wissensquellen werden die FuE-Beschäftigte im Privatsektor, die Größe der Universitäten und Fachhochschulen sowie das Volumen der von ihnen aus verschiedenen Quellen eingeworbenen Drittmittel berücksichtigt. Die Bedeutung dieser Wissensquellen wurde systematisch auf der Ebene der westdeutschen Kreise getestet, wobei Informationen sowohl über den jeweiligen Kreis als auch über die Nachbarkreise einbezogen wurden. Es stellt sich heraus, dass von der Qualität der in den Universitäten und Fachhochschulen betriebenen Forschung ein signifikanter Einfluss auf die regionale Innovationstätigkeit ausgeht. Die reine Größe der Universitäten und Fachhochschulen in der Region hat hingegen keinen Einfluss. Darüber hinaus ermitteln wir Unterschiede nach Herkunft von Drittmitteln sowie Unterschiede in der Bedeutung verschiedener Fachdisziplinen für regionale Innovationsaktivitäten. Wissensspillover sind im Wesentlichen auf die angrenzenden Kreise begrenzt.
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